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Champix varenicline has a specific dual mode of action that blocks nicotine to help break the addiction cycle in smokers1

Champix supports your patients on their smoking cessation journey.2-7

Champix is a partial agonist at the α4β2 nicotine acetylcholine receptor1

It's dual mode of action helps your patients with the symptoms associated with nicotine cravings and withdrawal.2-5

Action 1
Champix blocks nicotine to reduce the positive reinforcements of smoking1-4,6,7 - including enhanced mood or mental physical functioning.6

Action 2
Champix releases reduced levels of dopamine compared to nicotine1,2,6,7 to reduce cravings and withdrawal symptoms.1-3,6,7

1. Champix summary of product characteristics
2. Gonzales D, Rennard Sl, Nides M et al. Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, vs sustained release bupropion and placebo for smoking cessation. A randomized controlled trial. JAMA 2006; 296: 47-55.
3. West R, Baker CL, Cappelleri JC et al. Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt. Psychopharmacology 2008; 197: 371-377
4. Hughes JR, et al. Efficacy of varenicline to prompt quit attempts in smokers not currently trying to quit: A randomised placebo-controlled trial. Nicotine Tob Res. 2011;12:955-964
5. Hays JT, et al. Changes in health-related quality of life with smoking cessation treatment. Eur J Public Health. 2010;22:224-229.
6. Benowitz NL. Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics. Annu Rev Pharmacol Toxicol 2009; 49: 57-71.
7. Coe JW, Brooks PR, Vetelino MG et al. Varenicline: an α4β2 nicotinic receptor partial agonist for smoking cessation. JMed Chem 2005; 48: 3474-3477.

PP-CHM-GBR-1772. April 2018.

How CHAMPIX varenicline works