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Like all medicines, CHAMPIX can cause side effects, although not everybody gets them. This page provides a list of the possible side effects.

Very common: may affect more than 1 in 10 people

  • Inflammation of the nose and throat, abnormal dreams, difficulty sleeping, headache,
  • Nausea

Common: may affect up to 1 in 10 people

  • Chest infection, inflammation of the sinuses
  • Increased weight, decreased appetite, increased appetite
  • Sleepiness, dizziness, changes in the way things taste
  • Shortness of breath, cough
  • Heartburn, vomiting, constipation, diarrhoea, feeling bloated, abdominal pain, toothache, indigestion, flatulence, dry mouth
  • Skin rash, itching
  • Joint ache, muscle ache, back pain
  • Chest pain, tiredness

Uncommon: may affect up to 1 in 100 people

  • Fungal infection, viral infection
  • Feeling of panic, difficulty thinking, restlessness, mood swings, depression, anxiety, hallucinations, changes in sex drive
  • Seizure, tremor, feeling sluggish, less sensitive to touch
  • Conjunctivitis, eye pain
  • Ringing in the ears
  • Angina, rapid heart rate, palpitations, increased heart rate
  • Increased blood pressure, hot flush
  • Inflammation of nose, sinuses and throat, congestion of nose, throat and chest, hoarseness, hay fever, throat irritation, congested sinuses, excess mucous from nose causing cough, runny nose
  • Red blood in stools, irritated stomach, change of bowel habit, belching, mouth ulcers, pain in the gums
  • Reddening of the skin, acne, increased sweating, night sweats
  • Muscle spasms, chest wall pain
  • Abnormally frequent urination, urination at night
  • Increased menstrual flow
  • Chest discomfort, flu like illness, fever, feeling weak or unwell
  • High blood sugar
  • Heart attack
  • Suicidal thoughts
  • Changes in thinking or behaviour (such as aggression)

Rare: may affect up to 1 in 1,000 people

  • Excessive thirst
  • Feeling unwell or unhappy, slow thinking
  • Stroke
  • Increased muscle tension, difficulty with speech, difficulty with coordination, reduced sense of taste, altered sleep pattern
  • Disturbed vision, eyeball discolouration, dilated pupils, sensitivity to light, shortsightedness, watery eyes
  • Irregular heart beat or heart rhythm disturbances
  • Throat pain, snoring
  • Blood in vomit, abnormal stools, coated tongue
  • Stiff joints, rib pain
  • Glucose in urine, increased urine volume and frequency
  • Vaginal discharge, changes in sexual ability
  • Feeling cold, cyst
  • Diabetes
  • Sleep walking
  • Loss of contact with reality and unable to think or judge clearly (psychosis)
  • Abnormal behaviour
  • Severe skin reactions including Erythema Multiforme (a type of rash) and StevensJohnson Syndrome (a serious illness with blistering of the skin, mouth, around the eyes or genitals)
  • Serious allergic reactions including angioedema (swelling of the face, mouth, or throat)


  • Transient loss of consciousness

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed here or in the patient information leaflet.

By reporting side effects you can help provide more information on the safety of this medicine.

You can report side effects directly via the United Kingdom Yellow Card Scheme website: www.mhra.gov.uk/yellowcard


PP-INT-GBR-0036.  May 2020

List of Champix side effects